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Chemical structure of Orelabrutinib

GC39634

Orelabrutinib

Also known as 2-(4-phenoxyphenyl)-6-(1-prop-2-enoylpiperidin-4-yl)pyridine-3-carboxamide

Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity· Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK

ChemicalCAS1655504-04-3MW427.5FormulaC26H25N3O3
CAS number
1655504-04-3
Molecular weight
427.5
Formula
C26H25N3O3
Solubility
DMSO： 250 mg/mL (584·80 mM)
InChIKey
MZPVEMOYADUARK-UHFFFAOYSA-N
Catalogue number
GC39634
Brand
GLPBIO
Computed properties PubChem CID 91667513 · XLogP 3.6 · TPSA 85.5 Ų · H-bond donors 1
XLogP
3.6
TPSA
85.5 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
32

SMILES C=CC(=O)N1CCC(CC1)C2=NC(=C(C=C2)C(=O)N)C3=CC=C(C=C3)OC4=CC=CC=C4

Computed descriptors from PubChem (CID 91667513), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.