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Chemical structure of Orexin 2 Receptor Agonist

GC19272

Orexin 2 Receptor Agonist

Also known as N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist

ChemicalCAS1796565-52-0MW586.7FormulaC32H34N4O5S
CAS number
1796565-52-0
Molecular weight
586.7
Formula
C32H34N4O5S
Solubility
DMSO : ≥ 32 mg/mL (54·54 mM)
InChIKey
RHLMXWCISNJNDH-UHFFFAOYSA-N
Catalogue number
GC19272
Brand
GLPBIO
Computed properties PubChem CID 91810287 · XLogP 4.8 · TPSA 125 Ų · H-bond donors 3
XLogP
4.8
TPSA
125 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
11
Heavy atoms
42

SMILES CC1=CC(=CC=C1)C(=O)NCCNC2=CC(=CC=C2)NS(=O)(=O)C3=C(C=CC(=C3)C4=CC(=CC=C4)C(=O)N(C)C)OC

Computed descriptors from PubChem (CID 91810287), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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