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Chemical structure of HS-10296

GC39560

HS-10296

Also known as N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide

HS-10296 (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations· HS-10296 shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0·37, 0·29 and 0·21 nM, respectively), and is less effective against wild type (3·39 nM)· HS-10296 is used for the research of the non-small cell lung cancer

ChemicalCAS1899921-05-1MW525.64FormulaC30H35N7O2
CAS number
1899921-05-1
Molecular weight
525.64
Formula
C30H35N7O2
Solubility
DMSO： ≥ 83·33 mg/mL (158·53 mM)
InChIKey
DOEOECWDNSEFDN-UHFFFAOYSA-N
Catalogue number
GC39560
Brand
GLPBIO
Computed properties PubChem CID 121280087 · XLogP 4.2 · TPSA 87.6 Ų · H-bond donors 2
XLogP
4.2
TPSA
87.6 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
11
Heavy atoms
39

SMILES CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC

Computed descriptors from PubChem (CID 121280087), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.