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Chemical structure of HS-10296 hydrochloride

GC33053

HS-10296 hydrochloride

Also known as N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide;hydrochloride

Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations· HS-10296 hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0·37, 0·29 and 0·21 nM, respectively), and is less effective against wild type (3·39 nM)· HS-10296 hydrochloride is used for the research of the non-small cell lung cancer

ChemicalCAS2134096-03-8MW562.11FormulaC30H36ClN7O2
CAS number
2134096-03-8
Molecular weight
562.11
Formula
C30H36ClN7O2
Solubility
DMSO ： 83·33 mg/mL (148·25 mM)
InChIKey
CUXBWKDZKQGJNN-UHFFFAOYSA-N
Catalogue number
GC33053
Brand
GLPBIO
Computed properties PubChem CID 137319707 · TPSA 87.6 Ų · H-bond donors 3 · H-bond acceptors 7
TPSA
87.6 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
11
Heavy atoms
40

SMILES CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.Cl

Computed descriptors from PubChem (CID 137319707), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.