Loading...
Chemical structure of PROTAC SGK3 degrader-1

GC39426

PROTAC SGK3 degrader-1

Also known as (2S,4R)-1-[(2S)-2-[[2-[2-[2-[6-[(2R)-2-[[6-[4-[(2-fluoro-5-methylphenyl)sulfonylamino]phenyl]-1H-pyrazolo[5,4-d]pyrimidin-4-yl]oxymethyl]morpholin-4-yl]hexoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on von Hippel-Lindau ligand· PROTAC SGK3 degrader-1 (0·3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate)

ChemicalCAS2381320-35-8MW1157.38FormulaC57H73FN10O11S2
CAS number
2381320-35-8
Molecular weight
1157.38
Formula
C57H73FN10O11S2
Solubility
DMSO： ≥ 100 mg/mL (86·40 mM)
InChIKey
RTFQFPZKDYMMMJ-RIAKQDHQSA-N
Catalogue number
GC39426
Brand
GLPBIO
Computed properties PubChem CID 139035049 · XLogP 6 · TPSA 298 Ų · H-bond donors 5
XLogP
6
TPSA
298 Ų
H-bond donors
5
H-bond acceptors
19
Rotatable bonds
29
Heavy atoms
81

SMILES CC1=CC(=C(C=C1)F)S(=O)(=O)NC2=CC=C(C=C2)C3=NC4=C(C=NN4)C(=N3)OC[C@H]5CN(CCO5)CCCCCCOCCOCCOCC(=O)N[C@H](C(=O)N6C[C@@H](C[C@H]6C(=O)NCC7=CC=C(C=C7)C8=C(N=CS8)C)O)C(C)(C)C

Computed descriptors from PubChem (CID 139035049), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.