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Chemical structure of JNJ-46281222

GC39393

JNJ-46281222

Also known as 3-(cyclopropylmethyl)-7-[(4-phenylpiperidin-1-yl)methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1·7 nM) and a high modulatory potency (pEC50?= 7·71)

ChemicalCAS1254980-38-5MW414.47FormulaC23H25F3N4
CAS number
1254980-38-5
Molecular weight
414.47
Formula
C23H25F3N4
Solubility
DMSO： 62·5 mg/mL (150·79 mM)
InChIKey
LYDKDODJIBQNLK-UHFFFAOYSA-N
Catalogue number
GC39393
Brand
GLPBIO
Computed properties PubChem CID 49822115 · XLogP 5.5 · TPSA 33.4 Ų · H-bond donors 0
XLogP
5.5
TPSA
33.4 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
30

SMILES C1CC1CC2=NN=C3N2C=CC(=C3C(F)(F)F)CN4CCC(CC4)C5=CC=CC=C5

Computed descriptors from PubChem (CID 49822115), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.