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Chemical structure of FGTI-2734 mesylate

GC39276

FGTI-2734 mesylate

Also known as N-[2-[4-cyano-2-fluoro-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-N-(cyclohexylmethyl)pyridine-2-sulfonamide;methanesulfonic acid

FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively· FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors

ChemicalCAS2702297-24-1MW606.73FormulaC27H35FN6O5S2
CAS number
2702297-24-1
Molecular weight
606.73
Formula
C27H35FN6O5S2
Solubility
DMSO： 75 mg/mL (123·61 mM)
InChIKey
CVSSKDKRVCBPOV-UHFFFAOYSA-N
Catalogue number
GC39276
Brand
GLPBIO
Computed properties PubChem CID 145925655 · TPSA 166 Ų · H-bond donors 1 · H-bond acceptors 11
TPSA
166 Ų
H-bond donors
1
H-bond acceptors
11
Rotatable bonds
10
Heavy atoms
41

SMILES CN1C=NC=C1CN(CCN(CC2CCCCC2)S(=O)(=O)C3=CC=CC=N3)C4=C(C=C(C=C4)C#N)F.CS(=O)(=O)O

Computed descriptors from PubChem (CID 145925655), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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