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Chemical structure of 1-Naphthohydroxamic acid

GC39214

1-Naphthohydroxamic acid

Also known as N-hydroxynaphthalene-1-carboxamide

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM· 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM)· 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity·1-Naphthohydroxamic acid can induce tubulin acetylation

ChemicalCAS6953-61-3MW187.19FormulaC11H9NO2
CAS number
6953-61-3
Molecular weight
187.19
Formula
C11H9NO2
Solubility
DMSO： 125 mg/mL (667·77 mM)
InChIKey
JRZGPWOEHDOVMC-UHFFFAOYSA-N
Catalogue number
GC39214
Brand
GLPBIO
Computed properties PubChem CID 23382 · XLogP 2.4 · TPSA 49.3 Ų · H-bond donors 2
XLogP
2.4
TPSA
49.3 Ų
H-bond donors
2
H-bond acceptors
2
Rotatable bonds
1
Heavy atoms
14

SMILES C1=CC=C2C(=C1)C=CC=C2C(=O)NO

Computed descriptors from PubChem (CID 23382), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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