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Chemical structure of CNX-500

GC39083

CNX-500

Also known as N-[3-[2-[2-[3-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propoxy]ethoxy]ethoxy]propyl]-N'-[3-[3-[[5-methyl-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]propyl]pentanediamide

CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin· CNX-500 retains inhibitory activity against Btk (IC50 of 0·5 nM) and the ability to form a covalent bond with Btk· CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn

ChemicalCAS1202758-21-1MW961.18FormulaC48H68N10O9S
CAS number
1202758-21-1
Molecular weight
961.18
Formula
C48H68N10O9S
Solubility
Soluble in DMSO
InChIKey
SBOPEFHTOFMNSD-IAWMPOBQSA-N
Catalogue number
GC39083
Brand
GLPBIO
Computed properties PubChem CID 59174509 · XLogP 3.4 · TPSA 270 Ų · H-bond donors 8
XLogP
3.4
TPSA
270 Ų
H-bond donors
8
H-bond acceptors
14
Rotatable bonds
34
Heavy atoms
68

SMILES CC1=CN=C(N=C1NC2=CC(=CC=C2)NC(=O)C=C)NC3=CC(=CC=C3)OCCCNC(=O)CCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCC[C@H]4[C@@H]5[C@H](CS4)NC(=O)N5

Computed descriptors from PubChem (CID 59174509), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.