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Chemical structure of CNX-1351

GC19109

CNX-1351

Also known as 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methylhept-5-ene-1,4-dione

CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor with IC50 of 6·8 nM

ChemicalCAS1276105-89-5MW573.71FormulaC30H35N7O3S
CAS number
1276105-89-5
Molecular weight
573.71
Formula
C30H35N7O3S
Solubility
DMSO ： ≥ 21·8 mg/mL (38·00 mM)
InChIKey
DLNUPKDFXMWRFP-UHFFFAOYSA-N
Catalogue number
GC19109
Brand
GLPBIO
Computed properties PubChem CID 58441401 · XLogP 2.9 · TPSA 136 Ų · H-bond donors 1
XLogP
2.9
TPSA
136 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
41

SMILES CC(=CC(=O)CCC(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6)C

Computed descriptors from PubChem (CID 58441401), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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