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Chemical structure of PROTAC Mcl1 degrader-1

GC38943

PROTAC Mcl1 degrader-1

Also known as N'-[2-[6-(4-bromophenyl)sulfanyl-1,3-dioxobenzo[de]isoquinolin-2-yl]ethyl]-N-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]hexanediamide

PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0·78 μM· PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity

ChemicalCAS2163793-38-0MW909.84FormulaC45H45BrN6O8S
CAS number
2163793-38-0
Molecular weight
909.84
Formula
C45H45BrN6O8S
Solubility
DMSO： 50 mg/mL (54·95 mM)
InChIKey
BORXNUWYWZOREQ-UHFFFAOYSA-N
Catalogue number
GC38943
Brand
GLPBIO
Computed properties PubChem CID 139035048 · XLogP 6 · TPSA 216 Ų · H-bond donors 4
XLogP
6
TPSA
216 Ų
H-bond donors
4
H-bond acceptors
10
Rotatable bonds
19
Heavy atoms
61

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=C6C(=C(C=C5)SC7=CC=C(C=C7)Br)C=CC=C6C4=O

Computed descriptors from PubChem (CID 139035048), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.