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Chemical structure of PROTAC K-Ras Degrader-1

GC38942

PROTAC K-Ras Degrader-1

Also known as 2-[(2S)-4-[2-[[(2S,4R)-4-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile

PROTAC K-Ras Degrader-1 (Compound 518) is potent K-Ras degrader based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells

ChemicalCAS2378258-52-5MW999.12FormulaC53H62N10O10
CAS number
2378258-52-5
Molecular weight
999.12
Formula
C53H62N10O10
Solubility
DMSO： 33·33 mg/mL (33·36 mM)
InChIKey
KGFCORDWMRCVAC-VYIZRSQBSA-N
Catalogue number
GC38942
Brand
GLPBIO
Computed properties PubChem CID 139579413 · XLogP 3.7 · TPSA 221 Ų · H-bond donors 2
XLogP
3.7
TPSA
221 Ų
H-bond donors
2
H-bond acceptors
17
Rotatable bonds
22
Heavy atoms
73

SMILES CN1C[C@@H](C[C@H]1COC2=NC3=C(CCN(C3)C4=CC=CC5=CC=CC=C54)C(=N2)N6CCN([C@H](C6)CC#N)C(=O)C=C)OCCOCCOCCOCCNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O

Computed descriptors from PubChem (CID 139579413), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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