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Chemical structure of PROTAC Bcl2 degrader-1

GC38941

PROTAC Bcl2 degrader-1

Also known as N-[2-[6-(4-bromophenyl)sulfanyl-1,3-dioxobenzo[de]isoquinolin-2-yl]ethyl]-N'-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]hexanediamide

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4·94 μM; DC50, 3·0 μM) and Mcl-1 (IC50, 11·81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1

ChemicalCAS2378801-85-3MW941.84FormulaC45H45BrN6O10S
CAS number
2378801-85-3
Molecular weight
941.84
Formula
C45H45BrN6O10S
Solubility
DMSO： 25 mg/mL (26·54 mM)
InChIKey
IUSLKFLLLNNOGR-UHFFFAOYSA-N
Catalogue number
GC38941
Brand
GLPBIO
Computed properties PubChem CID 139035047 · XLogP 4.3 · TPSA 235 Ų · H-bond donors 4
XLogP
4.3
TPSA
235 Ų
H-bond donors
4
H-bond acceptors
12
Rotatable bonds
21
Heavy atoms
63

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=C6C(=C(C=C5)SC7=CC=C(C=C7)Br)C=CC=C6C4=O

Computed descriptors from PubChem (CID 139035047), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.