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Chemical structure of Fmoc-Gly-Gly-Phe-OtBu

GC38914

Fmoc-Gly-Gly-Phe-OtBu

Also known as tert-butyl (2S)-2-[[2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]-3-phenylpropanoate

Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

ChemicalCAS236426-37-2MW557.64FormulaC32H35N3O6
CAS number
236426-37-2
Molecular weight
557.64
Formula
C32H35N3O6
Solubility
DMSO: 200 mg/mL (358·65 mM)
InChIKey
XQLGBXCTOOARCT-MHZLTWQESA-N
Catalogue number
GC38914
Brand
GLPBIO
Computed properties PubChem CID 11103667 · XLogP 4.6 · TPSA 123 Ų · H-bond donors 3
XLogP
4.6
TPSA
123 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
13
Heavy atoms
41

SMILES CC(C)(C)OC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Computed descriptors from PubChem (CID 11103667), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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