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Chemical structure of BIP-135

GC38892

BIP-135

Also known as 3-(1-benzofuran-3-yl)-4-(5-bromo-1-methylindol-3-yl)pyrrole-2,5-dione

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively

ChemicalCAS941575-71-9MW421.24FormulaC21H13BrN2O3
CAS number
941575-71-9
Molecular weight
421.24
Formula
C21H13BrN2O3
Solubility
DMSO : 62·5 mg/mL (148·37 mM; Need ultrasonic (<70°C))
InChIKey
QKQJCKAXFJBYKJ-UHFFFAOYSA-N
Catalogue number
GC38892
Brand
GLPBIO
Computed properties PubChem CID 16741475 · XLogP 3.7 · TPSA 64.2 Ų · H-bond donors 1
XLogP
3.7
TPSA
64.2 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
2
Heavy atoms
27

SMILES CN1C=C(C2=C1C=CC(=C2)Br)C3=C(C(=O)NC3=O)C4=COC5=CC=CC=C54

Computed descriptors from PubChem (CID 16741475), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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