GC38812
MD-224
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept· MD-224 consists of ligands for Cereblon and MDM2· MD-224 induces rapid degradation of MDM2 at concentrations ＜1 nM in human leukemia cells, and achieves an IC50 value of 1·5 nM in inhibition of growth of RS4;11 cells· MD-224 has the potential to be a new class of anticancer agent
- CAS number
- 2136247-12-4
- Molecular weight
- 889.8
- Formula
- C48H43Cl2FN6O6
- Solubility
- DMSO： 150 mg/mL (168·58 mM); Water： ＜ 0·1 mg/mL (insoluble)
- InChIKey
- ZLGNYFOIDAVMHY-MPKOGUQCSA-N
- Catalogue number
- GC38812
- Brand
- GLPBIO
Computed properties PubChem CID 131986956 · XLogP 5.9 · TPSA 166 Ų · H-bond donors 5
- XLogP
- 5.9
- TPSA
- 166 Ų
- H-bond donors
- 5
- H-bond acceptors
- 8
- Rotatable bonds
- 9
- Heavy atoms
- 63
SMILES C1CCC2(CC1)[C@@]3([C@H]([C@@H](N2)C(=O)NC4=CC=C(C=C4)C(=O)NCCCC#CC5=C6CN(C(=O)C6=CC=C5)C7CCC(=O)NC7=O)C8=C(C(=CC=C8)Cl)F)C9=C(C=C(C=C9)Cl)NC3=O
Computed descriptors from PubChem (CID 131986956), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il