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Chemical structure of Mcl1-IN-8

GC38811

Mcl1-IN-8

Also known as (5Z)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-[(4-phenylphenyl)methylidene]-1,3-thiazol-4-one

Mcl1-IN-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0·3 μM· Mcl1-IN-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells

ChemicalCAS678158-55-9MW393.5FormulaC22H23N3O2S
CAS number
678158-55-9
Molecular weight
393.5
Formula
C22H23N3O2S
Solubility
DMSO： 50 mg/mL (127·06 mM)
InChIKey
IBEWMFVUBLAYJT-SILNSSARSA-N
Catalogue number
GC38811
Brand
GLPBIO
Computed properties PubChem CID 988971 · XLogP 3.2 · TPSA 81.4 Ų · H-bond donors 1
XLogP
3.2
TPSA
81.4 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
28

SMILES C1CN(CCN1CCO)C2=NC(=O)/C(=C/C3=CC=C(C=C3)C4=CC=CC=C4)/S2

Computed descriptors from PubChem (CID 988971), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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