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Chemical structure of J14

GC38803

J14

Also known as 4-[[4-[4-(2-chlorophenyl)piperazin-1-yl]-6-phenylpyrimidin-2-yl]sulfanylmethyl]benzoic acid

J14 is a reversible sulfiredoxin inhibitor with an IC50 of 8·1 μM· J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death

ChemicalCAS1043854-13-2MW517.04FormulaC28H25ClN4O2S
CAS number
1043854-13-2
Molecular weight
517.04
Formula
C28H25ClN4O2S
Solubility
DMSO： 260 mg/mL (502·86 mM)
InChIKey
RSHUJZXWKLIBRE-UHFFFAOYSA-N
Catalogue number
GC38803
Brand
GLPBIO
Computed properties PubChem CID 45987688 · XLogP 6.4 · TPSA 94.9 Ų · H-bond donors 1
XLogP
6.4
TPSA
94.9 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
36

SMILES C1CN(CCN1C2=CC=CC=C2Cl)C3=NC(=NC(=C3)C4=CC=CC=C4)SCC5=CC=C(C=C5)C(=O)O

Computed descriptors from PubChem (CID 45987688), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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