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Chemical structure of J22352

GC34629

J22352

Also known as 4-[[2,4-dioxo-3-(2-phenylethyl)quinazolin-1-yl]methyl]-N-hydroxybenzamide

J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4·7 nM· J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1

ChemicalCAS2252395-44-9MW415.44FormulaC24H21N3O4
CAS number
2252395-44-9
Molecular weight
415.44
Formula
C24H21N3O4
Solubility
DMSO： 125 mg/mL (300·89 mM)
InChIKey
JBJIKUXUKSADFV-UHFFFAOYSA-N
Catalogue number
GC34629
Brand
GLPBIO
Computed properties PubChem CID 138377601 · XLogP 3 · TPSA 90 Ų · H-bond donors 2
XLogP
3
TPSA
90 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
31

SMILES C1=CC=C(C=C1)CCN2C(=O)C3=CC=CC=C3N(C2=O)CC4=CC=C(C=C4)C(=O)NO

Computed descriptors from PubChem (CID 138377601), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.