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Chemical structure of DRF-1042

GC38774

DRF-1042

Also known as (19S)-19-ethyl-19-hydroxy-12-(2-hydroxyethoxy)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

DRF-1042 is an orally active derivative of Camptothecin· DRF-1042 acts to inhibit DNA topoisomerase I· DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype

ChemicalCAS200619-13-2MW408.4FormulaC22H20N2O6
CAS number
200619-13-2
Molecular weight
408.4
Formula
C22H20N2O6
Solubility
DMSO: 50 mg/mL (122·43 mM)
InChIKey
XAKLYHGHEFMDAP-IAXKEJLGSA-N
Catalogue number
GC38774
Brand
GLPBIO
Computed properties PubChem CID 23631031 · XLogP 0.3 · TPSA 109 Ų · H-bond donors 2
XLogP
0.3
TPSA
109 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
30

SMILES CC[C@@]1(C2=C(COC1=O)C(=O)N3C(C4=CC5=CC=CC=C5N=C4C3=C2)OCCO)O

Computed descriptors from PubChem (CID 23631031), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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