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Chemical structure of DRP1i27

GC69011

DRP1i27

Also known as (1S,5R)-3-[(5-methyl-1H-imidazol-4-yl)methyl]-6-[[5-(1H-pyrazol-5-yl)furan-2-yl]methyl]-3,6-diazabicyclo[3.2.2]nonane

DRP1i27 is an effective inhibitor of human Drp1 (dynamin-related protein 1)· DRP1i27 binds to the GTPase site of Drp1 and forms hydrogen bonds with Gln34 and Asp218· DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and prevents simulated ischemia-reperfusion injury

ChemicalCAS1453028-33-5MW366.46FormulaC20H26N6O
CAS number
1453028-33-5
Molecular weight
366.46
Formula
C20H26N6O
Solubility
DMSO ： 100 mg/mL (272·88 mM; Need ultrasonic)
InChIKey
PJYHAZFCIWUKAT-JKSUJKDBSA-N
Catalogue number
GC69011
Brand
GLPBIO
Computed properties PubChem CID 72901225 · XLogP 1.5 · TPSA 77 Ų · H-bond donors 2
XLogP
1.5
TPSA
77 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
27

SMILES CC1=C(N=CN1)CN2C[C@@H]3CC[C@H](C2)N(C3)CC4=CC=C(O4)C5=CC=NN5

Computed descriptors from PubChem (CID 72901225), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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