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Chemical structure of ZED-1227

GC37963

ZED-1227

Also known as methyl (E,6S)-7-[[1-[2-(2-ethylbutylamino)-2-oxoethyl]-2-oxo-3-pyridinyl]amino]-6-[(3-methylimidazole-4-carbonyl)amino]-7-oxohept-2-enoate

ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM

ChemicalCAS1542132-88-6MW528.6FormulaC26H36N6O6
CAS number
1542132-88-6
Molecular weight
528.6
Formula
C26H36N6O6
Solubility
DMSO ： 125 mg/mL (236·47 mM; Need ultrasonic)
InChIKey
VHGWUSABWIEXKQ-BEBFYNPSSA-N
Catalogue number
GC37963
Brand
GLPBIO
Computed properties PubChem CID 72950407 · XLogP 1.6 · TPSA 152 Ų · H-bond donors 3
XLogP
1.6
TPSA
152 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
15
Heavy atoms
38

SMILES CCC(CC)CNC(=O)CN1C=CC=C(C1=O)NC(=O)[C@H](CC/C=C/C(=O)OC)NC(=O)C2=CN=CN2C

Computed descriptors from PubChem (CID 72950407), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.