GC37726
TAK-960 hydrochloride
Also known as 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide;hydrochloride
TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0·8 nM· TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16·9 and 50·2 nM, respectively· TAK-960 hydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts
- CAS number
- 1137868-96-2
- Molecular weight
- 598.06
- Formula
- C27H35ClF3N7O3
- Solubility
- Soluble in DMSO
- InChIKey
- QZBHDFGFNVMONB-UHFFFAOYSA-N
- Catalogue number
- GC37726
- Brand
- GLPBIO
Computed properties PubChem CID 91826087 · TPSA 103 Ų · H-bond donors 3 · H-bond acceptors 11
- TPSA
- 103 Ų
- H-bond donors
- 3
- H-bond acceptors
- 11
- Rotatable bonds
- 6
- Heavy atoms
- 41
SMILES CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2F)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC.Cl
Computed descriptors from PubChem (CID 91826087), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il