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Chemical structure of TAK-659

GC37723

TAK-659

Also known as 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one

TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3·2 nM and 4·6 nM for SYK and FLT3, respectively· TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)

ChemicalCAS1312691-33-0MW344.39FormulaC17H21FN6O
CAS number
1312691-33-0
Molecular weight
344.39
Formula
C17H21FN6O
Solubility
Soluble in DMSO
InChIKey
MJHOMTRKVMKCNE-NWDGAFQWSA-N
Catalogue number
GC37723
Brand
GLPBIO
Computed properties PubChem CID 53252276 · XLogP 0.5 · TPSA 97.9 Ų · H-bond donors 3
XLogP
0.5
TPSA
97.9 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
25

SMILES CN1C=C(C=N1)C2=NC(=C(C3=C2C(=O)NC3)F)N[C@@H]4CCCC[C@@H]4N

Computed descriptors from PubChem (CID 53252276), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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