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Chemical structure of SPL-410

GC37675

SPL-410

Also known as N-[(2S,3S)-3-amino-2-hydroxy-3-[4-(trifluoromethoxy)phenyl]propyl]-4-tert-butyl-N-cyclobutylbenzenesulfonamide

SPL-410 is an orally active, highly potent and selective hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a) inhibitor, with an IC50 of 9 nM

ChemicalCAS2351886-00-3MW500.57FormulaC24H31F3N2O4S
CAS number
2351886-00-3
Molecular weight
500.57
Formula
C24H31F3N2O4S
Solubility
DMSO ： 190 mg/mL (379·57 mM; Need ultrasonic)
InChIKey
KEEHEUGOPCFXAV-VXKWHMMOSA-N
Catalogue number
GC37675
Brand
GLPBIO
Computed properties PubChem CID 138911346 · XLogP 4.8 · TPSA 101 Ų · H-bond donors 2
XLogP
4.8
TPSA
101 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
9
Heavy atoms
34

SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)N(C[C@@H]([C@H](C2=CC=C(C=C2)OC(F)(F)F)N)O)C3CCC3

Computed descriptors from PubChem (CID 138911346), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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