Loading...
Chemical structure of RU·521

GC37570

RU·521

Also known as 2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-(3-oxo-1H-2-benzofuran-1-yl)-1H-pyrazol-3-one

RU·521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor that binds to the catalytic domain of cGAS, thereby inhibiting the activation of cGAS by dsDNA· The IC50 value of RU·521 in inhibiting cGAS-mediated signal transduction is 700nM

ChemicalCAS2262452-06-0MW415.23FormulaC19H12Cl2N4O3
CAS number
2262452-06-0
Molecular weight
415.23
Formula
C19H12Cl2N4O3
Solubility
DMSO： ≥ 125 mg/mL (301·04 mM)
InChIKey
IAWZUQAOMURCLV-UHFFFAOYSA-N
Catalogue number
GC37570
Brand
GLPBIO
Computed properties PubChem CID 135397653 · XLogP 4.1 · TPSA 87.3 Ų · H-bond donors 2
XLogP
4.1
TPSA
87.3 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
2
Heavy atoms
28

SMILES CC1=C(C(=O)N(N1)C2=NC3=C(N2)C=CC(=C3Cl)Cl)C4C5=CC=CC=C5C(=O)O4

Computed descriptors from PubChem (CID 135397653), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.