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Chemical structure of PNU-159682

GC36941

PNU-159682

Also known as (7S,9S)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-7-[[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.02,7]tridecan-4-yl]oxy]-8,10-dihydro-7H-tetracene-5,12-dione

PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity· PNU-159682 acts as a more potent and tolerated?ADC cytotoxin than Doxorubicin for ADC synthesis· PNU-159682 can be used in EDV-nanocell technology to overcome drug resistance

ChemicalCAS202350-68-3MW641.62FormulaC32H35NO13
CAS number
202350-68-3
Molecular weight
641.62
Formula
C32H35NO13
Solubility
DMSO： ≥ 100 mg/mL (155·86 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
SLURUCSFDHKXFR-WWMWMSKMSA-N
Catalogue number
GC36941
Brand
GLPBIO
Computed properties PubChem CID 9874188 · XLogP 2.4 · TPSA 191 Ų · H-bond donors 4
XLogP
2.4
TPSA
191 Ų
H-bond donors
4
H-bond acceptors
14
Rotatable bonds
6
Heavy atoms
46

SMILES C[C@H]1[C@@H]2[C@H](C[C@@H](O1)O[C@H]3C[C@@](CC4=C3C(=C5C(=C4O)C(=O)C6=C(C5=O)C(=CC=C6)OC)O)(C(=O)CO)O)N7CCO[C@@H]([C@H]7O2)OC

Computed descriptors from PubChem (CID 9874188), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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