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Chemical structure of PK68

GC36933

PK68

Also known as cyclohexyl N-[5-(2-acetamido-1,3-benzothiazol-6-yl)-2-methyl-3-pyridinyl]carbamate

PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis

ChemicalCAS2173556-69-7MW424.52FormulaC22H24N4O3S
CAS number
2173556-69-7
Molecular weight
424.52
Formula
C22H24N4O3S
Solubility
DMSO： 30 mg/mL (70·67 mM)
InChIKey
DRCNWQYEKZTTEW-UHFFFAOYSA-N
Catalogue number
GC36933
Brand
GLPBIO
Computed properties PubChem CID 134203923 · XLogP 4.2 · TPSA 121 Ų · H-bond donors 2
XLogP
4.2
TPSA
121 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
30

SMILES CC1=C(C=C(C=N1)C2=CC3=C(C=C2)N=C(S3)NC(=O)C)NC(=O)OC4CCCCC4

Computed descriptors from PubChem (CID 134203923), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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