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Chemical structure of PF-06263276

GC36882

PF-06263276

Also known as [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2·2 nM, 23·1 nM, 59·9 nM and 29·7 nM for JAK1, JAK2, JAK3 and TYK2, respectively

ChemicalCAS1421502-62-6MW566.63FormulaC31H31FN8O2
CAS number
1421502-62-6
Molecular weight
566.63
Formula
C31H31FN8O2
Solubility
DMSO ： 33·33 mg/mL (58·82 mM; Need ultrasonic)
InChIKey
XDJGNPSZQSWJCV-UHFFFAOYSA-N
Catalogue number
GC36882
Brand
GLPBIO
Computed properties PubChem CID 135567296 · XLogP 4.1 · TPSA 127 Ų · H-bond donors 3
XLogP
4.1
TPSA
127 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
42

SMILES CCC1=CC(=C(C=C1C2=CC3=C(C=C2)C(=NN3)C4=NC5=C(N4)CN(CC5)C(=O)C6=CN=C(C=N6)N7CCCCC7)F)O

Computed descriptors from PubChem (CID 135567296), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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