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Chemical structure of MMAF-OMe

GC36634

MMAF-OMe

Also known as methyl (2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoate

MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin· MMAF-Ome inhibits several tumor cell lines with IC50s of 0·056 nM, 0·166 nM, 0·183 nM, and 0·449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively

ChemicalCAS863971-12-4MW745.99FormulaC40H67N5O8
CAS number
863971-12-4
Molecular weight
745.99
Formula
C40H67N5O8
Solubility
DMSO： ≥ 100 mg/mL (134·05 mM)
InChIKey
WRVLBJXFSHALRZ-FUVGGWJZSA-N
Catalogue number
GC36634
Brand
GLPBIO
Computed properties PubChem CID 57587881 · XLogP 4.7 · TPSA 156 Ų · H-bond donors 3
XLogP
4.7
TPSA
156 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
22
Heavy atoms
53

SMILES CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)OC)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC

Computed descriptors from PubChem (CID 57587881), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.