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Chemical structure of Masitinib mesylate

GC36546

Masitinib mesylate

Also known as methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide

Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit)· It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK· Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity

ChemicalCAS1048007-93-7MW594.75FormulaC29H34N6O4S2
CAS number
1048007-93-7
Molecular weight
594.75
Formula
C29H34N6O4S2
Solubility
DMSO： ≥ 30 mg/mL (50·44 mM)
InChIKey
TXCWBWKVIZGWEQ-UHFFFAOYSA-N
Catalogue number
GC36546
Brand
GLPBIO
Computed properties PubChem CID 25024769 · TPSA 164 Ų · H-bond donors 3 · H-bond acceptors 10
TPSA
164 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
7
Heavy atoms
41

SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5.CS(=O)(=O)O

Computed descriptors from PubChem (CID 25024769), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.