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Chemical structure of FIIN-3

GC36044

FIIN-3

Also known as N-[4-[[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide

FIIN-3 is an irreversible inhibitor of FGFR with an IC50 of 13·1, 21, 31·4, and 35·3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively

ChemicalCAS1637735-84-2MW691.61FormulaC34H36Cl2N8O4
CAS number
1637735-84-2
Molecular weight
691.61
Formula
C34H36Cl2N8O4
Solubility
DMSO： 10 mg/mL (14·46 mM and warming); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
SFLKJNSBBVSPFE-UHFFFAOYSA-N
Catalogue number
GC36044
Brand
GLPBIO
Computed properties PubChem CID 73707531 · XLogP 5.6 · TPSA 124 Ų · H-bond donors 3
XLogP
5.6
TPSA
124 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
11
Heavy atoms
48

SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(CC4=CC=C(C=C4)NC(=O)C=C)C(=O)NC5=C(C(=CC(=C5Cl)OC)OC)Cl

Computed descriptors from PubChem (CID 73707531), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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