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Chemical structure of FIPI hydrochloride

GB40196

FIPI hydrochloride

Also known as 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide;hydrochloride

Phospholipase D (PLD) inhibitor (IC50 values of 20-25 nM for both PLD1 and PLD2) that rapidly blocks in vivo phosphatidic acid (PA) production with subnanomolar potency· FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, PIP2 availability, cell spreading, and chemotA1is, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis

ChemicalCAS1781834-93-2MW457.93FormulaC23H24FN5O2·HCl
CAS number
1781834-93-2
Molecular weight
457.93
Formula
C23H24FN5O2·HCl
InChIKey
BNMQCDOCYPGJJD-UHFFFAOYSA-N
Catalogue number
GB40196
Brand
GLPBIO
Computed properties PubChem CID 90488864 · TPSA 80.5 Ų · H-bond donors 4 · H-bond acceptors 4
TPSA
80.5 Ų
H-bond donors
4
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
32

SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F.Cl

Computed descriptors from PubChem (CID 90488864), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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