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Chemical structure of eIF4A3-IN-1

GC35969

eIF4A3-IN-1

Also known as 3-[4-[(3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-5-methylpyrazol-1-yl]benzonitrile

eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0·26 μM; Kd=0·043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD

ChemicalCAS2095486-67-0MW588.88FormulaC29H23BrClN5O2
CAS number
2095486-67-0
Molecular weight
588.88
Formula
C29H23BrClN5O2
Solubility
Soluble in DMSO
InChIKey
BDGKKHWJYBQRIE-HHHXNRCGSA-N
Catalogue number
GC35969
Brand
GLPBIO
Computed properties PubChem CID 137640621 · XLogP 5.2 · TPSA 82.2 Ų · H-bond donors 0
XLogP
5.2
TPSA
82.2 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
38

SMILES CC1=C(C=NN1C2=CC=CC(=C2)C#N)C(=O)N3CCN([C@H](C3)C4=CC=C(C=C4)Cl)C(=O)C5=CC=C(C=C5)Br

Computed descriptors from PubChem (CID 137640621), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.