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Chemical structure of CX-6258 hydrochloride hydrate

GC35762

CX-6258 hydrochloride hydrate

Also known as (3E)-5-chloro-3-[[5-[3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]furan-2-yl]methylidene]-1H-indol-2-one;hydrate;hydrochloride

CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively

ChemicalCAS1353858-99-7MW516.42FormulaC26H27Cl2N3O4
CAS number
1353858-99-7
Molecular weight
516.42
Formula
C26H27Cl2N3O4
Solubility
DMSO: 25 mg/mL (48·41 mM)
InChIKey
ZOZTWDKBSOVPDP-LLDDCTHSSA-N
Catalogue number
GC35762
Brand
GLPBIO
Computed properties PubChem CID 74892460 · TPSA 66.8 Ų · H-bond donors 3 · H-bond acceptors 5
TPSA
66.8 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
35

SMILES CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.O.Cl

Computed descriptors from PubChem (CID 74892460), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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