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Chemical structure of BQ-788

GC35546

BQ-788

Also known as (2R)-2-[[(2R)-2-[[(2S)-2-[[(2S,6R)-2,6-dimethylpiperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]-3-(1-methoxycarbonylindol-3-yl)propanoyl]amino]hexanoic acid

BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1·2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM

ChemicalCAS173326-37-9MW641.8FormulaC34H51N5O7
CAS number
173326-37-9
Molecular weight
641.8
Formula
C34H51N5O7
Solubility
DMSO ： 100 mg/mL (155·81 mM; Need ultrasonic)
InChIKey
LPAHKJMGDSJDRG-DJYQTOCQSA-N
Catalogue number
GC35546
Brand
GLPBIO
Computed properties PubChem CID 5311032 · XLogP 5.8 · TPSA 159 Ų · H-bond donors 4
XLogP
5.8
TPSA
159 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
14
Heavy atoms
46

SMILES CCCC[C@H](C(=O)O)NC(=O)[C@@H](CC1=CN(C2=CC=CC=C21)C(=O)OC)NC(=O)[C@H](CC(C)(C)C)NC(=O)N3[C@@H](CCC[C@@H]3C)C

Computed descriptors from PubChem (CID 5311032), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.