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Chemical structure of AZD5153 6-Hydroxy-2-naphthoic acid

GC35448

AZD5153 6-Hydroxy-2-naphthoic acid

Also known as 6-hydroxynaphthalene-2-carboxylic acid;(3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one

AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153· AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1·7 nM

ChemicalCAS1869912-40-2MW667.75FormulaC36H41N7O6
CAS number
1869912-40-2
Molecular weight
667.75
Formula
C36H41N7O6
Solubility
DMSO: ≥ 34 mg/mL (50·92 mM)
InChIKey
UNZQBHXKCHECEC-GMUIIQOCSA-N
Catalogue number
GC35448
Brand
GLPBIO
Computed properties PubChem CID 118693658 · TPSA 146 Ų · H-bond donors 2 · H-bond acceptors 11
TPSA
146 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
8
Heavy atoms
49

SMILES C[C@@H]1C(=O)N(CCN1CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5OC)C=C4)C.C1=CC2=C(C=CC(=C2)O)C=C1C(=O)O

Computed descriptors from PubChem (CID 118693658), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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