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Chemical structure of AZD5363

GC11752

AZD5363

Also known as 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

AZD5363 is a selective inhibitor of the protein kinases AKT1, AKT2, and AKT3, with IC₅₀ values of 3, 7, and 7nM, respectively· AZD5363 targets the PI3K/AKT/mTOR signaling pathway and has demonstrated anti-tumor activity and potential therapeutic applications in various cancers

ChemicalCAS1143532-39-1MW428.92FormulaC21H25ClN6O2
CAS number
1143532-39-1
Molecular weight
428.92
Formula
C21H25ClN6O2
Solubility
≥ 21·45mg/mL in DMSO
InChIKey
JDUBGYFRJFOXQC-KRWDZBQOSA-N
Catalogue number
GC11752
Brand
GLPBIO
Computed properties PubChem CID 25227436 · XLogP 1.7 · TPSA 120 Ų · H-bond donors 4
XLogP
1.7
TPSA
120 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
30

SMILES C1CN(CCC1(C(=O)N[C@@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4

Computed descriptors from PubChem (CID 25227436), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.