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Chemical structure of Pexidartinib hydrochloride

GC34708

Pexidartinib hydrochloride

Also known as 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)-3-pyridinyl]methyl]pyridin-2-amine;hydrochloride

Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively· Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases· Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity

ChemicalCAS2040295-03-0MW454.28FormulaC20H16Cl2F3N5
CAS number
2040295-03-0
Molecular weight
454.28
Formula
C20H16Cl2F3N5
Solubility
DMSO ： 60 mg/mL (132·08 mM)
InChIKey
CJLUYLRKLUYCEK-UHFFFAOYSA-N
Catalogue number
GC34708
Brand
GLPBIO
Computed properties PubChem CID 73053710 · TPSA 66.5 Ų · H-bond donors 3 · H-bond acceptors 7
TPSA
66.5 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
30

SMILES C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F.Cl

Computed descriptors from PubChem (CID 73053710), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.