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Chemical structure of Pexidartinib

GC12222

Pexidartinib

Also listed as Pexidartinib (PLX3397)

Pexidartinib(PLX3397) is an orally administered small molecule tyrosine kinase inhibitor with potent selective activity against the colony-stimulating factor 1(CSF1) receptor(IC50=20nM), KIT proto-oncogene receptor tyrosine kinase(KIT)(IC50 =10nM) and FMS-like tyrosine kinase

ChemicalCAS1029044-16-3MW417.81FormulaC20H15ClF3N5
CAS number
1029044-16-3
Molecular weight
417.81
Formula
C20H15ClF3N5
Solubility
≥ 20·9mg/mL in DMSO
InChIKey
JGWRKYUXBBNENE-UHFFFAOYSA-N
Catalogue number
GC12222
Brand
GLPBIO
Computed properties PubChem CID 25151352 · XLogP 4.5 · TPSA 66.5 Ų · H-bond donors 2
XLogP
4.5
TPSA
66.5 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
29

SMILES C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F

Computed descriptors from PubChem (CID 25151352), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.