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Chemical structure of GSK467

GC34604

GSK467

Also known as 2-(1-benzylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-one

GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM· GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members

ChemicalCAS1628332-52-4MW319.32FormulaC17H13N5O2
CAS number
1628332-52-4
Molecular weight
319.32
Formula
C17H13N5O2
Solubility
DMSO ： 20·83 mg/mL (65·23 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
ZTYRLXUTLYBVHH-UHFFFAOYSA-N
Catalogue number
GC34604
Brand
GLPBIO
Computed properties PubChem CID 135567128 · XLogP 1.5 · TPSA 81.4 Ų · H-bond donors 1
XLogP
1.5
TPSA
81.4 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
24

SMILES C1=CC=C(C=C1)CN2C=C(C=N2)OC3=NC4=C(C=CN=C4)C(=O)N3

Computed descriptors from PubChem (CID 135567128), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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