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Chemical structure of BI-749327

GC34489

BI-749327

Also known as [4-(6-aminopyridazin-3-yl)piperidin-1-yl]-[4-[4-(trifluoromethyl)phenoxy]phenyl]methanone

BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively

ChemicalCAS2361241-23-6MW442.43FormulaC23H21F3N4O2
CAS number
2361241-23-6
Molecular weight
442.43
Formula
C23H21F3N4O2
Solubility
DMSO ： 31·25 mg/mL (70·63 mM)
InChIKey
RGYMFGHHIDRCBN-UHFFFAOYSA-N
Catalogue number
GC34489
Brand
GLPBIO
Computed properties PubChem CID 138377580 · XLogP 3.6 · TPSA 81.3 Ų · H-bond donors 1
XLogP
3.6
TPSA
81.3 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
32

SMILES C1CN(CCC1C2=NN=C(C=C2)N)C(=O)C3=CC=C(C=C3)OC4=CC=C(C=C4)C(F)(F)F

Computed descriptors from PubChem (CID 138377580), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.