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Chemical structure of PROTAC ERα Degrader-1

GC34341

PROTAC ERα Degrader-1

Also known as 4-[(3S,4S)-7-cyano-1-[(2-methoxynaphthalen-1-yl)methyl]-4-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-2-oxo-3,4-dihydro-1,5-benzodiazepine-5-carbonyl]-N-[2-[2-[2-[2-[4-[(Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenoxy]ethyl-methylamino]-2-oxoethoxy]ethoxy]ethyl]benzamide

PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group· PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1· PROTAC ERα Degrader-1 is an estrogen receptor-alpha (ERα) degrader

ChemicalCAS2417369-94-7MW1120.29FormulaC66H69N7O10
CAS number
2417369-94-7
Molecular weight
1120.29
Formula
C66H69N7O10
Solubility
DMSO： 200 mg/mL (178·53 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
SNBOCOFSYPHJLP-XJQCFLMPSA-N
Catalogue number
GC34341
Brand
GLPBIO
Computed properties PubChem CID 132144837 · XLogP 9.4 · TPSA 212 Ų · H-bond donors 4
XLogP
9.4
TPSA
212 Ų
H-bond donors
4
H-bond acceptors
12
Rotatable bonds
24
Heavy atoms
83

SMILES CC/C(=C(\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCN(C)C(=O)COCCOCCNC(=O)C3=CC=C(C=C3)C(=O)N4[C@H]([C@@H](C(=O)N(C5=C4C=C(C=C5)C#N)CC6=C(C=CC7=CC=CC=C76)OC)NC(=O)[C@H](C)NC)C)/C8=CC=CC=C8

Computed descriptors from PubChem (CID 132144837), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.