Loading...
Chemical structure of ERK-IN-1

GC33206

ERK-IN-1

Also known as 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide

ERK-IN-1 (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway· The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer· ERK-IN-1 hydrochloride can also inhibit RAF

ChemicalCAS1715025-32-3MW578.42FormulaC26H27BrF3N5O2
CAS number
1715025-32-3
Molecular weight
578.42
Formula
C26H27BrF3N5O2
Solubility
Soluble in DMSO
InChIKey
YFCIFWOJYYFDQP-PTWZRHHISA-N
Catalogue number
GC33206
Brand
GLPBIO
Computed properties PubChem CID 118045847 · XLogP 3.1 · TPSA 113 Ų · H-bond donors 4
XLogP
3.1
TPSA
113 Ų
H-bond donors
4
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
37

SMILES CNC[C@H](C1=CC(=CC(=C1)Br)F)NC(=O)C2=C(C=C(C=C2)C3=NC(=CN=C3N)[C@H]4CC[C@@H]([C@H](C4)F)O)F

Computed descriptors from PubChem (CID 118045847), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.