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Chemical structure of Intoplicine

GC33165

Intoplicine

Also known as 16-[3-(dimethylamino)propylamino]-13-methyl-11,15-diazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(10),2(7),3,5,8,12(17),13,15-octaen-5-ol

Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor· Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA

ChemicalCAS125974-72-3MW348.44FormulaC21H24N4O
CAS number
125974-72-3
Molecular weight
348.44
Formula
C21H24N4O
Solubility
Soluble in DMSO
InChIKey
QROONAIPJKQFMC-UHFFFAOYSA-N
Catalogue number
GC33165
Brand
GLPBIO
Computed properties PubChem CID 65954 · XLogP 4.3 · TPSA 64.2 Ų · H-bond donors 3
XLogP
4.3
TPSA
64.2 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
26

SMILES CC1=CN=C(C2=C1NC3=C2C4=C(C=C3)C=C(C=C4)O)NCCCN(C)C

Computed descriptors from PubChem (CID 65954), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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