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Chemical structure of Forodesine

GC33029

Forodesine

Also listed as Forodesine (BCX-1777 freebase)

Forodesine (BCX-1777 freebase) (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0·48 to 1·57 nM for human, mouse, rat, monkey and dog PNP· Forodesine (BCX-1777 freebase) is a potent human lymphocyte proliferation inhibitor· Forodesine (BCX-1777 freebase) could induce apoptosis in leukemic cells by increasing the dGTP levels

ChemicalCAS209799-67-7MW266.25FormulaC11H14N4O4
CAS number
209799-67-7
Molecular weight
266.25
Formula
C11H14N4O4
Solubility
PBS (pH 7·2)： 5 mg/ml
InChIKey
IWKXDMQDITUYRK-KUBHLMPHSA-N
Catalogue number
GC33029
Brand
GLPBIO
Computed properties PubChem CID 135409409 · XLogP -2.3 · TPSA 130 Ų · H-bond donors 6
XLogP
-2.3
TPSA
130 Ų
H-bond donors
6
H-bond acceptors
6
Rotatable bonds
2
Heavy atoms
19

SMILES C1=C(C2=C(N1)C(=O)NC=N2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O

Computed descriptors from PubChem (CID 135409409), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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