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Chemical structure of Tipifarnib (S enantiomer)

GC33007

Tipifarnib (S enantiomer)

Also listed as Tipifarnib S enantiomer ((S)-(-)-R-115777)

Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib· Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0·6 nM· Tipifarnib S enantiomer is the less active isomer

ChemicalCAS192185-71-0MW489.4FormulaC27H22Cl2N4O
CAS number
192185-71-0
Molecular weight
489.4
Formula
C27H22Cl2N4O
Solubility
DMSO: 25 mg/mL (51·08 mM)
InChIKey
PLHJCIYEEKOWNM-MHZLTWQESA-N
Catalogue number
GC33007
Brand
GLPBIO
Computed properties PubChem CID 9935249 · XLogP 4.1 · TPSA 64.2 Ų · H-bond donors 1
XLogP
4.1
TPSA
64.2 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
34

SMILES CN1C=NC=C1[C@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N

Computed descriptors from PubChem (CID 9935249), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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