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Chemical structure of SHR-1258 dimaleate

GC32989

SHR-1258 dimaleate

Also listed as Pyrotinib dimaleate (SHR-1258 dimaleate)

Pyrotinib dimaleate (SHR-1258 dimaleate) (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively

ChemicalCAS1397922-61-0MW815.22FormulaC40H39ClN6O11
CAS number
1397922-61-0
Molecular weight
815.22
Formula
C40H39ClN6O11
Solubility
Water ： ≥ 106 mg/mL (130·03 mM)
InChIKey
KLHFGQSCVQPTIN-XUZAKNADSA-N
Catalogue number
GC32989
Brand
GLPBIO
Computed properties PubChem CID 72710866 · TPSA 262 Ų · H-bond donors 6 · H-bond acceptors 16
TPSA
262 Ų
H-bond donors
6
H-bond acceptors
16
Rotatable bonds
14
Heavy atoms
58

SMILES CCOC1=C(C=C2C(=C(C=NC2=C1)C#N)NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)NC(=O)/C=C/[C@@H]5N(CCC5)C.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O

Computed descriptors from PubChem (CID 72710866), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.