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Chemical structure of TPOP146

GC32880

TPOP146

Also known as 7-(3,5-dimethoxyphenyl)-N-[(3S)-1-methylpiperidin-3-yl]-4-propanoyl-3,5-dihydro-2H-1,4-benzoxazepine-9-carboxamide

TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5·02 μM for CBP and BRD4

ChemicalCAS2018300-62-2MW481.58FormulaC27H35N3O5
CAS number
2018300-62-2
Molecular weight
481.58
Formula
C27H35N3O5
Solubility
DMSO ： ≥ 100 mg/mL (207·65 mM)
InChIKey
CUJLWYCUPPPASA-NRFANRHFSA-N
Catalogue number
GC32880
Brand
GLPBIO
Computed properties PubChem CID 122172830 · XLogP 2.9 · TPSA 80.3 Ų · H-bond donors 1
XLogP
2.9
TPSA
80.3 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
35

SMILES CCC(=O)N1CCOC2=C(C1)C=C(C=C2C(=O)N[C@H]3CCCN(C3)C)C4=CC(=CC(=C4)OC)OC

Computed descriptors from PubChem (CID 122172830), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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