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Chemical structure of GSK2850163

GC32857

GSK2850163

Also known as (5R)-2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-2,7-diazaspiro[4.5]decane-7-carboxamide

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively

ChemicalCAS2121989-91-9MW446.41FormulaC24H29Cl2N3O
CAS number
2121989-91-9
Molecular weight
446.41
Formula
C24H29Cl2N3O
Solubility
DMSO ： 67·5 mg/mL (151·21 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
YFDASBFQKMHSSJ-XMMPIXPASA-N
Catalogue number
GC32857
Brand
GLPBIO
Computed properties PubChem CID 73291790 · XLogP 4.9 · TPSA 35.6 Ų · H-bond donors 1
XLogP
4.9
TPSA
35.6 Ų
H-bond donors
1
H-bond acceptors
2
Rotatable bonds
4
Heavy atoms
30

SMILES CC1=CC=C(C=C1)CNC(=O)N2CCC[C@@]3(C2)CCN(C3)CC4=CC(=C(C=C4)Cl)Cl

Computed descriptors from PubChem (CID 73291790), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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